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Researchers at the University of California (UC) Cancer Biology Institute are working with material scientists at the University of Houston to study how to use nanotubes to obtain and understand the regularity of proteins that cause various diseases, including specific cancers and cardiovascular diseases. And obesity.
A study recently published in the Journal of the American Chemical Society, Applied Materials & Interfaces, showed that titania nanotubes grown on titanium-based metal wires have the efficacy of condensing phosphopeptides and provide key regulatory mechanisms for normal biological and cellular functions. The application of this mechanism is much simpler, which also means the use of cheaper and more practical materials in scientific research.
Associate Professor of Cancer Biology, co-author of the study, and Dr. Ken Greis, who also serves on the UC Cancer Society and the Cincinnati Cancer Center, said: "Protein phosphorylation is a central regulatory mechanism of normal cellular functions and biological processes in the body when the phosphorylation process is disrupted. It can cause the appearance of various diseases, including cardiovascular disease, nervous system diseases, endocrine diseases and cancer."
The study of the kinetic mechanism of the phosphorylation process has become a hot topic in biological research. Research institutions are dedicated to revealing the cellular mechanisms underlying the disease and developing new therapeutic interventions.
Greis said that the typical method of protein phosphorylation (phosphorylation proteomics) research is to separate and classify proteins by liquid chromatography and mass spectrometry. Concentration by adding metallic materials is necessary to help isolate. Greis also said: "Mesoporous titanium dioxide particles are widely used in the concentration of phosphopeptides, but they are relatively expensive and can hardly enhance new functions." Titanium dioxide nanotubes grown on titanium wires have been shown to be responsible for the separation of phosphopeptides. Very promising features. In this study, we evaluated the phosphoproteomic properties of nanotubes on titanium wires.
The researchers used titanium-based titanium dioxide nanotubes for a set of known standard phosphopeptides, and then applied phosphopeptides extracted from the liver tissue of hundreds of animals. Finally, the researchers compared the results with those of commercial particles. .
Greis said: "Our research shows that titania nanotubes grown on metal wires have comparable phosphopeptide concentrations and are easier to use relative to the particle structure. This can reduce costs and be more effective in future studies." The length and size of the tube are adjustable, which also opens the way for the future development of enrichment technology. This is also an exciting cooperation, highlighting the advantages of scientific exchanges between different disciplines.
The subject exchange started with a discussion between two institutions and then developed into a collaboration with Prof. Oomman Varghese, chief science and technology expert at Boston University to prepare titanium dioxide nanotubes for use as chemical sensors and solar energy conversion technologies.
He is an associate professor at the Boston University School of Physics. The other authors of the study were Dr. Aruna Wijeratne, Bo Hou of Greis Labs, Wei-Kan Chu, Distinguished Professor; Dr. Dharshana Wijesundera, Bo Hou; Maggie Paulose, Research Scientist; Ivy Belinda Ahiabu, Postgraduate, both from Boston University Physics system.
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